Could this theory work long term ? That stopped basically too 100 percent when i started taking B6/P5P which is involved in glucose metabolism. I have PTSD and take Effexor for it, plus cannabis, melatonin, and magnesium to help me sleep. I've no idea if saffron is any better for you though. Btw, I ve read that 5htp competes with the same enzyme which creates dopamine and norepinephrine this way preventing their production . I had a bottle at home, and had tried some earlier but it didn't do anything, so i was curious to see what it's effect might be after having plugged a nutrient-deficiency involved in the neurotransmitter-metabolism. Alone it wasn't enough around heavy anxiety triggers though. If you get positive results, you can increase your dosage to the desired amount. The effect on my depression was also huge: it totally eliminated my depression; and it did not feel forced like antidepressants, but much more natural, just like it wasnt present at all. Ask your therapist first and always start low. In alternative medicine, 5-HTP supplements are purported to help in the treatment of conditions including: 1. only spark the complex physiochemical changes your brain undergoes during the therapy with these drugs that leads to their antidepressant effects. Other uses not proven with research have included insomnia, alcohol withdrawal, headaches, premenstrual syndrome, binge-eating related to obesity, attention deficit disorder, and muscle spasms in the mouth. 5-HTP increases a brain chemical called serotonin. 5-HTP and venlafaxine both deal with serotonin levels in the brain, and taking the two at the same time is not recommended, according to Dr. Alan Gaby of ''A-Z Guide to Drug-Herb-Vitamin Interactions.' I’m looking for experiences and counter arguments to this thesis. Yes it could interact with Effexor ,although it’s not an classic Ssri, but it could give you serotonine syndrome which could be deadly . The good news is that CBD actually improves it, so it may be worth making your night time smoke one that's 50/50 CBD:THC. Beneath it, just the blackest emptiness and dark thoughts. It seems to help me a little. Thank you very much. Depression is not just about a "chemical imbalance" that only involves modifying serotonin pathways in the brain. I used 5-htp on and off through the years with some perceived efficacy, however after reading that 5-htp increases blood levels of serotonin more than brain levels and that B6 makes this worse, I decided to switch to L-Tryptophan. Often the actual tablet strength is the problem. Melatonin is even worse. Anything else besides 5htp that has worked in these regards? This is fascinating. Your brain is much more unpredictable and complicated than that. I use the 5-HTP to curb my carbohydrate cravings (Diabetes2 and can't tolerate the preservative chemicals in Insulin).... That depressive episode you describe is pretty much how I felt after returning to eating wheat...after a long time abstaining....no more...! With 5htp for sure you’re going to have very good results as I just described . I am definitely out of my depths here, but I know these basics: - Wellbutrin is an aminoketone classed as an atypical antidepressant NDRI, thus predominantly works on reuptake inhibition of the norepinephrine and dopamine transporters. Any side effects after a while ( in ptsd sufferers ) . Check the latest 5-HTP prices (11) Modafinil. So I heard of 5-htp at the start of this year, someone told me it was a serotonin booster but I figured it wasn't something you would actually medicate with. Hey, this isn't what you asked but looking at what you're using I wanna offer a recommendation maybe- thc is immensely helpful to me as well for sleep, but it does lower sleep quality. 100mg of 5 HTP is way too much and can turn you into a sleepy zombie but you don't sleep. Both SSRI antidepressants and MAOI inhibitors are known to have issues with additional 5-HTP. I'm currently looking for a mood booster. It will help you understand how stuff works on your body. Do you know if it interacts with prescription meds? I had anxiety so intense it felt like somebody was knifing me. After realising i was showing every clinical sign there is of B6-deficiency, i tried supplementing it in it's active form, P5P. You might want to read this. I'm not arguing for SSRI therapy at all - you need to focus on lowering stress and loving yourself (mentally, emotionally, even spiritually if you feel inclined) and eating more healthily. I also started having these very vivid dreams every single night, but they where not nightmares or in any way unpleasant. I got a bit scared off of 5htp because it is the direct precursor to serotonin, it isn't to be fucked with. I'd recommend trying saffron as a 5-htp alternative. The tablet strengths are insanely high. Would be very thankful for some feedback and help at this stage. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. Sleep quality will likely improve quite a bit and it saves on flower. No vitamins, no serotonin. 5-HTP (5-Hydroxy-L-tryptophan) is a substance that is made in the body from the amino acid, tryptophan, as an intermediate step in the body’s manufactuing of serotonin, an important neurtransmitter (brain chemical). P5P managed to completely kill my depressive episode in three days and i was back to feeling good. Its effect kick in in 30 minutes, faster than most antidepressants work. 5-HTP has been used in alternative medicine as a possibly effective aid in treating depression or fibromyalgia. Fibromyalgia 5. Choline was amazing for me. Since i did manage to completely recover from my depressive episode once, my motivation is still sky high. 5-htp crosses the blood brain barrier and converts to serotonin, a lack of which is believed to be involved in depression and anxiety. Hi. The supplements subreddit aims to discuss and share topics related to nutritional supplementation. Press question mark to learn the rest of the keyboard shortcuts. 5-hydroxytryptophan, also known as 5-HTP, is a dietary supplement made from the seeds of the African plant Griffonia simplicifolia. The main warning for supplements containing 5HTP is “do not consume if you’re taking antidepressant drugs.” This is because antidepressant drugs also affect serotonin levels, but in a different way to 5HTP. Is the reason just BIG pharma? While 5-HTP increases serotonin and melatonin initially, it does so at the expense of other equally important neurotransmitters. Can I ask, as you seem well versed on the subject, does serotonin by itself have a calming effect on the amygdala? Not diagnosed with ptsd, but I have symptoms, and reading that about adrenaline rushes as a behavioral mechanism rings a bell. 5-HTP (5-hydroxytryptophan) for Insomnia: “Just a few comments regarding 5 HTP and Melatonin. I am supplementing B6 and it actually helps with the conversion to brain levels of serotonin with L-Tryptophan. 5-HTP, which stands for 5-hydroxytryptophan (also called 5-HT), is considered a complementary treatment for depression, and studies to date on its effectiveness for treating depression have been inconclusive. r/5htp: Personal experiences using the supplement 5-HTP. Thanks. Ok. I’ll try it to alternate from 5htp when not working. Both have similar effects for me, they improve my sleep and dreams + starts my day with that chill zen good mood feeling. Try it and give you feedback something to fuck with and take Effexor for it, is a controlled... 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